黄酮类活性化合物库 Probe+
黄酮类活性化合物库 Probe+
产品名 产品编码 分子库数量 产品包装 (DMSO溶液/10mM)
黄酮类活性化合物库Probe+ LA-1003 黄酮类活性分子52个
M 系列 163个
C系列165个
96孔板:
10 μL/well, 20 μL/well, 或100 μL/well

 

       黄酮类化合物广泛存在于自然界的植物中,属植物次生代谢产物。黄酮类化合物是以黄酮(2-苯基色原酮)为母核而衍生的一类黄色色素。黄酮类化合物广泛存在于植物体内,具有强抗氧化性、抑菌抑酶特性、抗肿瘤等多功效的天然产物。

       该库目前收录了黄酮类化合物52个,其M+C系列的衍生物已达到~330个,并在持续快速地增加,为药物筛选提供多种以黄酮类化合物为母核、本库的仍在持续增加,为药物筛选提供全新的多样化的筛选工具。

 

 

图 1 黄酮类活性化合物已知相关疾病领域

 

 

表2 黄酮类活性化合物药物靶点示例

Cytochrome P450 1A2/1B1/1A1 (by homology) Xanthine dehydrogenase/oxidase Aldehyde oxidase (by homology) Microtubule-associated protein tau
Aldose reductase Aldo-keto reductase family 1 member B15/B10 (by homology) NADPH oxidase 4 Alcohol dehydrogenase [NADP(+)] (by homology)
1,5-anhydro-D-fructose reductase (by homology) Multidrug resistance-associated protein 1 Canalicular multispecific organic anion transporter 1/2 (by homology) Sodium/glucose cotransporter 1/2
Low affinity sodium-glucose cotransporter ATP-binding cassette sub-family G member 2 Carbonyl reductase [NADPH] 1/3 Plasmin light chain B
Apolipoprotein(a) (by homology) Estradiol 17-beta-dehydrogenase 1 Retinol dehydrogenase 8 (by homology) Tyrosyl-DNA phosphodiesterase 1
[flavin-containing] A/B (by homology) Beta amyloid A4 protein Adenosine receptor A3/A1 Cyclin-dependent kinase 1/2/3/4/6
Muscleblind-like protein 1/2 Dual specificity tyrosine-phosphorylation-regulated kinase 1A (by homology) Alpha-2A adrenergic receptor Prostaglandin G/H synthase 1/2 (by homology)
Nitric oxide synthase Aldehyde dehydrogenase Cytosolic 10-formyltetrahydrofolate dehydrogenase (by homology) Mitochondrial 10-formyltetrahydrofolate dehydrogenase (by homology)
3-oxo-5-alpha-steroid 4-dehydrogenase 1 cGMP-specific 3',5'-cyclic phosphodiesterase Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (by homology) Epidermal growth factor receptor
Receptor tyrosine-protein kinase erbB-2 (by homology) ERBB4 intracellular domain (by homology) Carbonic anhydrase Beta-secretase 1/2
3-phosphoinositide-dependent protein kinase 1 Cyclic AMP-responsive element-binding protein 1 FAD-linked sulfhydryl oxidase ALR Arachidonate 12-lipoxygenase, 12S-type (by homology)
 
Induced myeloid leukemia cell differentiation protein Mcl-1 22 kDa interstitial collagenase Stromelysin-1/-2 Macrophage metalloelastase

 

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