多酚类活性化合物库 Target Probe+
多酚类活性化合物库 Target Probe+
产品名 产品编码 分子库数量 产品包装 (DMSO溶液/10mM)
多酚类活性化合物库 Target Probe+ LA-1002 多酚类活性分子198个
M 系列 427个
C系列522个
96孔板:
10 μL/well, 20 μL/well, 或100 μL/well

 

       多酚类化合物主要指一类由两个及以上羟基(-OH)或甲氧基(-OMe)直接与芳香烃基团结合而成的天然产物,广泛存在于植物体内,具有强抗氧化性、抑菌抑酶特性、抗肿瘤等多功效的天然产物,主要的结构包括黄酮类、醌类、生物碱类、苯丙素类以及其它多酚类。

       该库目前包括多酚类天然产物198个,涵盖了市场上大部分用于药物筛选的多酚类天然产物,后衍生修饰后的M+C系列的已达到~950个。本库的仍在持续增加,为药物筛选提供全新的多样化的筛选工具。

 

图 1 多酚类活性化合物已知相关疾病领域

 

 

表2 多酚类活性化合物药物靶点示例

Microtubule-associated protein tau Cytochrome P450 1B1/19A1 Aldo-keto reductase family 1 member B15/B10 (by homology) Xanthine dehydrogenase
Carbonic anhydrase Estrogen receptor Nitric oxide synthase Tyrosyl-DNA phosphodiesterase 1
Arachidonate 5-lipoxygenase Aldose reductase (by homology) Epidermal growth factor receptor erbB1 Cyclooxygenase 2
Cannabinoid receptor 2 Adenosine A1 receptor (by homology) Quinone reductase 2 Dual specificity mitogen-activated protein kinase 1
P-glycoprotein 1 Multidrug resistance-associated protein 1 5-hydroxytryptamine receptor 1A/1B Epidermis-type lipoxygenase 3 (by homology)
Quinone oxidoreductase (by homology) ATP-binding cassette sub-family G member 2 Caspase-3 subunit p12 Caspase-7 subunit p20 (by homology)
Caspase-6 subunit p18 (by homology) Sodium/myo-inositol cotransporter (by homology) Sodium/glucose cotransporter 4/5 Mitochondrial
Plasmin light chain B Apolipoprotein(a) (by homology) Prostaglandin G/H synthase 1/2 (by homology) Serine/threonine-protein kinase/endoribonuclease IRE1
Beta amyloid A4 protein; ATP-binding cassette sub-family G member 2 Cyclooxygenase 1 Sodium/glucose cotransporter 1/2 Aldehyde dehydrogenase
Solute carrier family 28 member 3 Arachidonate 15-lipoxygenase B Interleukin-2 Low affinity sodium-glucose cotransporter
Inosine-5'-monophosphate dehydrogenase Cell division control protein 42 homolog Ras-related C3 botulinum toxin substrate 1 Epoxide hydratase
Adenosine A3 receptor Phosphodiesterase 5A Neutrophil elastase Azurocidin (by homology)
Myeloblastin (by homology) 3-oxo-5-alpha-steroid 4-dehydrogenase 1/2 Cytosolic 10-formyltetrahydrofolate dehydrogenase Retinal dehydrogenase 1/2
Amine oxidase [flavin-containing] A/B NADPH oxidase 4 Estradiol 17-beta-dehydrogenase 2 Corticosteroid 11-beta-dehydrogenase isozyme 2 (by homology)
Dual specificity tyrosine-phosphorylation-regulated kinase 1A Muscleblind-like protein Canalicular multispecific organic anion transporter 2 (by homology) FAD-linked sulfhydryl oxidase ALR
绿色:与原天然产物的靶点相同;黑色:新靶点

 

了解详情