产品名 | 产品编码 | 产品包装 (DMSO溶液/10mM) |
酚类活性化合物库 Target Probe+ | LA-1001 | 96孔板/384孔板: 10 μL/well, 20 μL/well, 或100 μL/well |
酚类化合物主要指一类由羟基(-OH)或甲氧基(-OMe)直接与芳香烃基团结合而成的,具有强抗氧化性、抑菌抑酶特性、抗肿瘤等多功效的天然产物。
产品名 | 产品编码 | 产品包装 (DMSO溶液/10mM) |
酚类活性化合物库 Target Probe+ | LA-1001 | 96孔板/384孔板: 10 μL/well, 20 μL/well, 或100 μL/well |
酚类化合物主要指一类由羟基(-OH)或甲氧基(-OMe)直接与芳香烃基团结合而成的,具有强抗氧化性、抑菌抑酶特性、抗肿瘤等多功效的天然产物。
图1 酚类活性化合物已知相关疾病领域
表2 酚类活性化合物已知药物靶点示例
Microtubule-associated protein tau | Cytochrome P450 1B1/19A1 | Aldo-keto reductase family 1 member B15/B10 (by homology) | Xanthine dehydrogenase |
Carbonic anhydrase | Estrogen receptor | Nitric oxide synthase | Tyrosyl-DNA phosphodiesterase 1 |
Arachidonate 5-lipoxygenase | Aldose reductase (by homology) | Epidermal growth factor receptor erbB1 | Cyclooxygenase 2 |
Cannabinoid receptor 2 | Adenosine A1 receptor (by homology) | Quinone reductase 2 | Dual specificity mitogen-activated protein kinase 1 |
P-glycoprotein 1 | Multidrug resistance-associated protein 1 | 5-hydroxytryptamine receptor 1A/1B | Epidermis-type lipoxygenase 3 (by homology) |
D(2) dopamine | DNA polymerase alpha catalytic subunit | NAD(P)H dehydrogenase [quinone] 1 (by homology) | Ribosyldihydronicotinamide dehydrogenase [quinone] |
Melatonin receptor type 1A/1B | Melatonin-related receptor (by homology) | Dual specificity tyrosine-phosphorylation-regulated kinase 1A (by homology) | Prostaglandin G/H synthase 1/2 |
Quinone oxidoreductase (by homology) | ATP-binding cassette sub-family G member 2 | Caspase-3 subunit p12 | Caspase-7 subunit p20 (by homology) |
Caspase-6 subunit p18 (by homology) | Sodium/myo-inositol cotransporter (by homology) | Sodium/glucose cotransporter 4/5 | Mitochondrial |
Plasmin light chain B | Apolipoprotein(a) (by homology) | Prostaglandin G/H synthase 1/2 (by homology) | Serine/threonine-protein kinase/endoribonuclease IRE1 |
Beta amyloid A4 protein; ATP-binding cassette sub-family G member 2 | Cyclooxygenase 1 | Sodium/glucose cotransporter 1/2 | Aldehyde dehydrogenase |
Solute carrier family 28 member 3 | Arachidonate 15-lipoxygenase B | Interleukin-2 | Low affinity sodium-glucose cotransporter |
Inosine-5'-monophosphate dehydrogenase | Cell division control protein 42 homolog | Ras-related C3 botulinum toxin substrate 1 | Epoxide hydratase |
Adenosine A3 receptor | Phosphodiesterase 5A | Neutrophil elastase | Azurocidin (by homology) |
绿色:与原天然产物的靶点相同;黑色:新靶点 |